八年临床、放射学及生存率结果：高密度自体软骨细胞植入治疗膝关节软骨损伤
简介
124例膝关节软骨损伤患者接受高密度自体软骨细胞移植（HD-ACI）后随访8年，疼痛VAS从6.7降至1.1，IKDC从39.4升至81.6，MOCART评分随时间持续改善，植入物8年存活率97.5%。该大样本回顾性队列证实HD-ACI可安全、持久地缓解疼痛并改善功能，为软骨修复的临床决策提供了长期生存证据。
英文摘要
BackgroundArticular cartilage lesions of the knee are difficult to manage due to their limited healing capacity. High-Density Autologous Chondrocyte Implantation (HD-ACI) has emerged as a promising treatment for symptom relief and functional recovery.MethodsThis retrospective study included 124 patients (88 men, 36 women; median age 35.5 years) with symptomatic chondral lesions of the knee treated with HD-ACI between 2010 and 2016. Patients were followed for up to 8 years. Visual Analogue Scale (VAS) for pain, International Knee Documentation Committee (IKDC) scores for knee function, and MOCART scores based on MRI evaluations of cartilage repair tissue were used for clinical assessment.ResultsPain significantly decreased from a mean VAS of 6.7 to 1.1 at 8 years (p<0.001). IKDC scores improved from 39.4 to 81.6 (p<0.001), being higher than the minimal clinically important difference (MCID). MOCART scores progressively increased over time. Knee mobility in both extension and flexion showed statistically significant improvement. Adverse events were mild and infrequent. Kaplan-Meier analysis showed an implant survival of 97.5% and an overall treatment survival of 92.6% at 8 years.ConclusionsHD-ACI is a safe and effective treatment for knee cartilage lesions, with long-term improvements in pain, joint function, confirmed clinically and radiologically.