早期步态训练影响前交叉韧带重建术后膝关节软骨退变的生物力学机制：一项研究方案
简介
该研究为一项单盲随机对照试验方案，计划纳入60例单侧ACLR患者，在术后3周开始为期6周的早期步态训练（使用反重力 treadmill）。主要发现假设：早期步态训练能显著改善术后步态生物力学，可能通过优化膝关节负荷预防或延缓软骨退变。该方案对ACLR后康复策略的优化具有参考价值，但尚需等待2年随访结果验证。
英文摘要
OBJECTIVE: The primary objective of this study is to investigate the effects and biomechanical mechanisms of early gait retraining (GRT) on knee cartilage degeneration following anterior cruciate ligament reconstruction (ACLR). METHODS: This study is a single-blind, parallel-group randomized controlled trial. A total of 60 participants scheduled for primary unilateral ACLR will be recruited and randomly allocated to either the experimental group (conventional rehabilitation plus gait retraining) or the control group (conventional rehabilitation only). Gait retraining will commence at 3 weeks post-surgery, lasting for 6 weeks with a frequency of 2-3 sessions per week, each lasting 15-20 min. Data will be collected at baseline (pre-intervention) and at 3 months, 6 months, 1 year, and 2 years postoperatively. Assessment will include three-dimensional gait analysis, surface electromyography (sEMG), isokinetic muscle strength testing, functional magnetic resonance imaging (fMRI), Y-balance test, single-leg hop test, the International Knee Documentation Committee (IKDC) subjective knee evaluation form, Lysholm knee score, and Tegner activity scale. The primary outcome measure is the peak knee flexion moment during walking. Secondary outcomes include cartilage T1ρ/T2 values, muscle activation patterns, and subjective functional scores. A repeated-measures analysis of variance (ANOVA) will be used to evaluate the intervention effects on the outcome measures. RESULTS: Not applicable. CONCLUSION: Early gait retraining using a lower-body positive pressure (anti-gravity) treadmill after ACLR is hypothesized to significantly improve postoperative gait biomechanics. Furthermore, early GRT may optimize standard rehabilitation protocols, potentially preventing or delaying cartilage degeneration. This approach holds clinical significance for restoring normal gait and preventing secondary injuries in individuals with sports-related injuries. CLINICAL TRIAL REGISTRATION: https:register.clinicaltrials.gov, identifier NCT06368544.