脱细胞猪异种移植物用于前交叉韧带重建的低失败率和满意患者报告结局指标：中年人群短期结果
简介
本研究纳入48例接受脱细胞猪源异种移植物（Orthopure®）行前交叉韧带（ACL）重建的患者（初次重建42例，翻修6例），平均年龄39.9岁，平均随访19.5个月。结果显示：移植物失败率4.1%（2例），再手术率8.1%（4例，因胫骨骨道扩大或内固定物相关并发症）；94%患者达到可接受症状状态（PASS），IKDC和Tegner评分较术前显著改善。临床意…
英文摘要
PURPOSE: To evaluate the short-term outcomes of arthroscopic anterior cruciate ligament (ACL) reconstruction (ACLR) using a decellularized porcine xenograft, focusing on patient-reported outcome measures (PROMs), complications and failure rates. METHODS: This retrospective study included 48 patients who underwent primary or revision ACLR with the Orthopure® xenograft. Preoperative and post-operative International Knee Documentation Committee (IKDC) and Tegner scores were collected and showed remarkable improvements at different follow-ups. Complications, reinterventions and failure rates were assessed. Post-operative evaluations were conducted at 6, 12 and 24 months of follow-up. The percentage of patients who achieved the patient acceptable symptom state (PASS) was calculated too. RESULTS: The mean age at surgery was 39.9 ± 8.5 years, with a mean follow-up of 19.5 ± 7.0 months. Primary ACLR was performed in 42 patients (87.5%), and revision surgery in 6 patients (12.5%). An associated meniscal procedure was performed in 38 cases (79.2%). Reoperation was required in 4 patients (8.1%) due to tibial tunnel enlargement or hardware-related complications. Graft failure occurred in 2 patients (4.1%). PASS was achieved in 45 patients (94%). CONCLUSION: ACLR using a porcine-derived xenograft appears to be a safe procedure with good clinical outcomes, a low rate of complications and graft failure. However, further studies with longer follow-up and including high-risk patients are warranted to better assess the long-term performance of this graft. LEVEL OF EVIDENCE: Level IV, case-series.