T1ρ和T2 mapping磁共振成像预测早期前交叉韧带损伤中软骨丢失的价值
简介
一项多中心前瞻性研究纳入50例早期前交叉韧带（ACL）损伤患者，采用T1ρ和T2 mapping MRI评估关节软骨成分与厚度。关键发现：ACL损伤膝关节T1ρ和T2值升高，软骨厚度减少；弛豫时间升高与早期软骨退变相关，尤其在损伤时间较长及合并半月板病变的患者中更明显。临床意义：T1ρ和T2 mapping MRI可作为无创工具，早期检测ACL损伤后软骨退变…
英文摘要
INTRODUCTION: Early cartilage degeneration after anterior cruciate ligament (ACL) injury often precedes structural changes detectable on conventional imaging. AIM: To evaluate the role of T1ρ and T2 mapping magnetic resonance imaging (MRI) in detecting early cartilage changes and predicting cartilage loss in ACL-injured knees. MATERIALS AND METHODS: A multicentric prospective observational study was conducted on 50 patients with early ACL injury. Quantitative MRI with T1ρ and T2 mapping was performed to assess cartilage composition and thickness. The study protocol was approved by the Institutional Ethics Committee, and written informed consent was obtained from all patients before inclusion. RESULTS: ACL-injured knees demonstrated elevated T1ρ and T2 values along with reduced cartilage thickness. Higher relaxation times correlated with early cartilage degeneration, particularly in patients with longer injury duration and associated meniscal pathology. CONCLUSION: T1ρ and T2 mapping MRI are effective non-invasive tools for early detection of cartilage degeneration and may aid in predicting cartilage loss following ACL injury.