足球运动员ACL重建术后二次ACL损伤的系统综述与Meta分析
简介
这是一项针对足球运动员前交叉韧带重建（ACLR）术后二次ACL损伤发生率的系统综述与荟萃分析，共纳入34项研究（16,905例运动员，50.5%为男性）。关键发现：二次ACL损伤的总体发生率为21.6%（95% CI 17.9%-25.9%），其中对侧损伤（10.6%）与同侧移植物损伤（10.4%）发生率相近。女性运动员（23.5%）高于男性（14.5%），…
英文摘要
PURPOSE: To determine the incidence of second anterior cruciate ligament (ACL) injuries in football players after index ACL reconstruction (ACLR). Secondary objectives were to assess second ACL injury rates across subgroups (laterality, sex, age, playing level, graft type, return to play [RTP] and follow-up duration) and to review factors associated with reinjury. METHODS: A systematic review and meta-analysis were conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, EMBASE and the Cochrane Library were searched from inception to 10 December 2025. Studies reporting second ACL injuries or subsequent ACLRs in football players were included. Incidence was defined as the proportion of players sustaining a subsequent ACL injury or ACLR relative to those undergoing index ACLR. RTP was defined as participation in at least one official match. Key limitations include substantial heterogeneity across studies, the inclusion of mixed data sources and the operational definition of second ACL injury, combining ACL injuries (graft rupture or contralateral tear) or, when not reported, subsequent ACLRs. RESULTS: Thirty-four studies (16,905 players; 50.5% male) were included. The pooled incidence of second ACL injury was 21.6% (95% confidence interval [CI] 17.9%-25.9%). Contralateral (10.6%, 95% CI 8.0%-13.9%) and ipsilateral injuries (10.4%, 95% CI 8.4%-12.9%) were of similar magnitude. Higher pooled incidence was observed in female (23.5%, 95% CI 18.0%-30.1%) compared with male players (14.5%, 95% CI 14.5%-23.4%), with 30% increased odds (odds ratio [OR] 1.3, 95% CI 1.1%-1.7%, p < 0.01). Among professionals, incidence was 19.2% (95% CI 15.1%-24.2%). No significant differences were found between hamstring tendon and bone-patellar tendon-bone (BPTB) autografts. The highest rates were observed in players <21 years (31.9%, 95% CI 23.6%-41.6%) and in cohorts with high RTP rates (29.2%, 95% CI 24.7%-34.1%). CONCLUSION: Second ACL injuries are common in football, affecting roughly between one in three to one in five players after ACLR. Higher rates of second ACL injury were observed in female players, younger individuals, those who returned to play, and in studies with longer follow-up duration. Contralateral ACL injuries had a similar magnitude to ipsilateral injuries. No significant differences in ipsilateral ACL reinjury rates were found between hamstrings tendon and BPTB autografts. LEVEL OF EVIDENCE: Level IV, systematic review and meta-analysis.